TAP Family: Zinc finger, ZPR1
<a target="_blank" class="awithout" href="http://pfam.xfam.org/family/PF03367">PFAM</a> (0): The zinc-finger protein ZPR1 is localised to the cytoplasm in quiescent cells; in proliferating cells treated with EGF or with other mitogens it accumulates in the nucleolus. Upon stimulation by EGF, ZPR1 directly binds the eukaryotic translation elongation factor-1alpha (eEF-1alpha) to form ZPR1/eEF-1alpha complexes. These move into the nucleus, localising particularly at the nucleolus. ZPR1 is thought to be involved in pre-ribosomal RNA expression. The ZPR1 domain consists of an elongation initiation factor 2-like zinc finger and a double-stranded beta helix with a helical hairpin insertion.
References:
Lang, D; Weiche, B; Timmerhaus, G; Richardt, S; Riano-Pachon, DM; Correa, LG; Reski, R; Mueller-Roeber, B; Rensing, SA. 2010. Genome-wide phylogenetic comparative analysis of plant transcriptional regulation: a timeline of loss, gain, expansion, and correlation with complexity. Genome Biol Evol. 2: 488-503
Gangwani, L1; Mikrut, M; Galcheva-Gargova, Z; Davis, RJ. 1998. Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells. J Cell Biol 143(6):1471-84"
Galcheva-Gargova, Z; Gangwani, L; Konstantinov, KN; Mikrut, M; Theroux, SJ; Enoch, T; Davis RJ. 1998. The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells. Mol Biol Cell 9(10):2963-71"
